                         SEQUENCE LISTING

<110>  KIRCHNER, Jacqueline A
       BRASEL, Kenneth A
       OLSON, Kara
       ESCOBAR, Jose Carlos
       BARONE, Dauphine
 
<120>  Human GM-CSF Antigen Binding Proteins

<130>  A-1292-WO-PCT

<140>  to be assigned
<141>  2008-09-18

<150>  60/994,343
<151>  2007-09-18

<150>  61/087,551
<151>  2008-08-08

<160>  147   

<170>  PatentIn version 3.2

<210>  1
<211>  240
<212>  PRT
<213>  Artificial Sequence 

<220>
<223>  light chain

<400>  1

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Ile Leu Tyr Ser Ser Ser Asn Glu Asn Phe Leu Thr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Phe Ser Val Phe Arg Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  2
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  2
atggtgctgc agacccaggt gtttattagc ctgctgctgt ggattagcgg cgcgtatggc     60

gacatcgtgc tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc    120

atcaactgca agtccagcca gagtatttta tacagctcca gcaatgagaa cttcttaact    180

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg    240

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc    300

atcagcagcc tgcagcctga agatgtggca gtttattact gtcagcaata ttttagtgtt    360

tttcggacgt tcggccaagg gaccagggtg gaaatcaaac gtacggtggc tgcaccatct    420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc    480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc    540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc    600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc    660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt    720


<210>  3
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  3

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Ser Asn Glu Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ser Val Phe Arg Thr Phe Gly Gln Gly Thr Arg Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  4

Lys Ser Ser Gln Ser Ile Leu Tyr Ser Ser Ser Asn Glu Asn Phe Leu 
1               5                   10                  15      


Thr 
    


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  5

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  6

Gln Gln Tyr Phe Ser Val Phe Arg Thr 
1               5                   


<210>  7
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  7

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Ser Ala 
65                  70                  75                  80  


Gln Lys Phe Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Gly Tyr Ser Tyr Gly Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
225                 230                 235                 240 


Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  8
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  8
atggattgga cctggcgtat tctgtttctg gtggcggcgg cgaccggcgc gcatagccag     60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgcaaggctt ctggatacac cttcaccggc tactatatac actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactctgca    240

cagaagtttc ggggcagggt caccatgacc agggacacgt ccatcagcac agcctacatg    300

gagctgagca ggctgagatc tgacgacacg gccgtgtatt actgtgcgcg agagggtgga    360

tacagctatg gttactttga ctactggggc cagggaaccc tggtcaccgt ctcctcagct    420

agcaccaagg gcccatcggt cttccccctg gcgccctgct ccaggagcac ctccgagagc    480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    540

aactcaggcg ctctgaccag cggcgtgcac accttcccag ctgtcctaca gtcctcagga    600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca acttcggcac ccagacctac    660

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagacagt tgagcgcaaa    720

tgttgtgtcg agtgcccacc gtgcccagca ccacctgtgg caggaccgtc agtcttcctc    780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacgtgcgtg    840

gtggtggacg tgagccacga agaccccgag gtccagttca actggtacgt ggacggcgtg    900

gaggtgcata atgccaagac aaagccacgg gaggagcagt tcaacagcac gttccgtgtg    960

gtcagcgtcc tcaccgttgt gcaccaggac tggctgaacg gcaaggagta caagtgcaag   1020

gtctccaaca aaggcctccc agcccccatc gagaaaacca tctccaaaac caaagggcag   1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag   1140

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag   1200

agcaatgggc agccggagaa caactacaag accacacctc ccatgctgga ctccgacggc   1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc   1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc   1380

ctgtctccgg gtaaa                                                    1395


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence 

<220>
<223>  variable domain

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Ser Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Tyr Ser Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  10

Gly Tyr Tyr Ile His 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  11

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Ser Ala Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  12

Glu Gly Gly Tyr Ser Tyr Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  13
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  13

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asp Arg Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  14
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  14
atggaaaccc cggcgcagct gctgtttctg ctgctgctgt ggctgccgga taccaccggc     60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga cagagccacc    120

ctctcctgca gggccagtca gagtgttagt agcagctact ttgcctggta ccagcagaaa    180

cctggccagg ctcccaggct cctcatttat ggtgcatcca gtagggccac tggcatccca    240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    300

cctgaagatt ttgcagtgta ttactgtcag cagtatgata ggtcacctcg gacgttcggc    360

caagggacca aggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg    420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc    540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg    600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag    660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                    705


<210>  15
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  15

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  16

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Phe Ala 
1               5                   10          


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  17

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  18

Gln Gln Tyr Asp Arg Ser Pro Arg Thr 
1               5                   


<210>  19
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  19

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ser Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Lys Trp Leu Asp Gly Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  20
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  20
atggattgga cctggcgtat tctgtttctg gtggcggcgg cgaccggcgc gcatagccag     60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgtaagtctt ctggatacac cttcaccggc tactatatgc actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactatgca    240

cagaagttta agggcagggt caccatgacc agggacacgt ccatcagcac agcctacatg    300

gagctgagca ggctgagatc tgacgacacg gccgtgtatt actgtgcgag agataagtgg    360

ctggacggct ttgactactg gggccaggga accctggtca ccgtctcctc agctagcacc    420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac    600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc    660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt    720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc    780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg    900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc    960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga   1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc   1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1380

ccgggtaaa                                                           1389


<210>  21
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Lys Trp Leu Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  22

Gly Tyr Tyr Met His 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  23

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  24

Asp Lys Trp Leu Asp Gly Phe Asp Tyr 
1               5                   


<210>  25
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  25

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asp Arg Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  26
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  26
atggaaaccc cggcgcagct gctgtttctg ctgctgctgt ggctgccgga taccaccggc     60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc    120

ctctcctgca gggccagtca gagtgttagc agcagctact tcgcctggta ccaacagaaa    180

cctggccagg ctcccaggct cctcatctat ggtacatcca gcagggccac tggcatccca    240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccgtcag cagactggag    300

cctgaggatt ttgcagtgta ttactgtcag cagtatgata ggtcacctcg gacgttcggc    360

caagggacca aggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg    420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc    540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg    600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag    660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                    705


<210>  27
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  27

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Tyr or Ser

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Gln or Arg

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Arg or Gln

<400>  28

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Xaa Ala Xaa Xaa Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  29

Gly Thr Ser Ser Arg Ala Thr 
1               5           


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser or Tyr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val, Ile or Leu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ser or Cys

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ser, Thr or Ile

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Phe or Leu

<400>  30

Arg Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Tyr Xaa Ala 
1               5                   10          


<210>  31
<211>  463
<212>  PRT
<213>  Artificial Sequence sequence

<220>
<223>  heavy chain

<400>  31

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Ser Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Asp Arg Trp Leu Asp Ala Phe Asp Ile Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  32
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  32
atggattgga cctggcgtat tctgtttctg gtggcggcgg cgaccggcgc gcatagccag     60

gtgcagttgg tgcagtctgg ggctgcggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgcaaggctt ctggatacac cttcaccggc tactatatac actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactatgca    240

caaaagtttc agggcagggt caccatgacc agggacacgt ccatcagcac agcctccatg    300

gaactgagca ggctgagatc tgacgacacg gccgtttatt tctgtgcgag agatcggtgg    360

ctggatgctt ttgatatctg gggccaaggg acaatggtca ccgtctcttc tgctagcacc    420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac    600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc    660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt    720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc    780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg    900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc    960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga   1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc   1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1380

ccgggtaaa                                                           1389


<210>  33
<211>  118
<212>  PRT
<213>  Artificial Sequence 

<220>
<223>  variable domain

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Ser 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Trp Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ala or Thr

<400>  34

Gly Xaa Ser Ser Arg Ala Thr 
1               5           


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  35

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  36

Asp Arg Trp Leu Asp Ala Phe Asp Ile 
1               5                   


<210>  37
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  37

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Tyr 
        35                  40                  45              


Ile Ser Asn Thr Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ala Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  38
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  38
atggaaaccc cggcgcagct gctgtttctg ctgctgctgt ggctgccgga taccaccggc     60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc    120

ctctcctgca gggccagtca gtatattagc aacacctatt tagcctggtt ccagcagaaa    180

cctggccagg ctcccaggct cctcatctat ggtgcagcca ccagggccac tggcatccca    240

gacaggttca gtggcagtgg gtctgggaca gacttcactt tcaccatcag cagactggag    300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc    360

caagggacca cggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg    420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc    540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg    600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag    660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                    705


<210>  39
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  39

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Tyr Ile Ser Asn Thr 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ala Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys 
            100                 105             


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  40

Arg Ala Ser Gln Tyr Ile Ser Asn Thr Tyr Leu Ala 
1               5                   10          


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  41

Gly Ala Ala Thr Arg Ala Thr 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  42

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  43
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  43

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Arg Phe Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Pro Tyr Asp Trp Thr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  44
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  44
atggattgga cctggcgtat tctgtttctg gtggcggcgg cgaccggcgc gcatagccag     60

gtgcagttgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgcaaggctt ctggatacac cttcaccggc tactatatgc actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactatgca    240

cagaggtttc ggggcagggt caccatgacc agggacacgt ccatcagcac agcctacatg    300

gaactgagca ggctgagatc tgacgacacg gccgtgtatt actgtgcgag agccccgtat    360

gactggacct ttgactactg gggccaggga accctggtca ccgtctcctc agctagcacc    420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac    600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc    660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt    720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc    780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg    900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc    960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga   1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc   1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1380

ccgggtaaa                                                           1389


<210>  45
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Tyr Asp Trp Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Tyr or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Phe, Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser, Thr or Trp

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val, Ser or Phe

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Arg, Trp, or Ile

<400>  46

Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa Thr 
1               5                   


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  47

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Arg Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  48

Ala Pro Tyr Asp Trp Thr Phe Asp Tyr 
1               5                   


<210>  49
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  49

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Cys Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Ser Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asp Arg Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  50
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  50
atggaaaccc cggcgcagct gctgtttctg ctgctgctgt ggctgccgga taccaccggc     60

gaagttgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc    120

ctctcctgca gggccagtca gagcgtttgc agcagctact tagcctggta ccagcagaaa    180

cctgaccagg ctcccaggct cctcatctct ggtgcgtcca gcagggccac tggcatccca    240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctggag    300

cctgaagatt ttgcagtgta ttactgtcag cagtatgata ggtcacctcg gacgttcggc    360

caagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg    420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc    540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg    600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag    660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                    705


<210>  51
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  51

Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Cys Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ser Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  52

Arg Ala Ser Gln Ser Val Cys Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  53
<211>  144
<212>  PRT
<213>  Macaca fascicularis

<400>  53

Met Trp Leu Gln Gly Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Gly Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Lys Thr Val Glu Val Val Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Ser Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Gln Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Gln Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  54
<211>  144
<212>  PRT
<213>  Canis familiaris

<400>  54

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Thr Val Val Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Thr Leu Val Thr Arg Pro Ser Gln His 
            20                  25                  30          


Val Asp Ala Ile Gln Glu Ala Leu Ser Leu Leu Asn Asn Ser Asn Asp 
        35                  40                  45              


Val Thr Ala Val Met Asn Lys Ala Val Lys Val Val Ser Glu Val Phe 
    50                  55                  60                  


Asp Pro Glu Gly Pro Thr Cys Leu Glu Thr Arg Leu Gln Leu Tyr Lys 
65                  70                  75                  80  


Glu Gly Leu Gln Gly Ser Leu Thr Ser Leu Lys Asn Pro Leu Thr Met 
                85                  90                  95      


Met Ala Asn His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Ser Pro 
            100                 105                 110         


Cys Ala Thr Gln Asn Ile Asn Phe Lys Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp Lys Pro Val Lys Lys 
    130                 135                 140                 


<210>  55
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  55

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Arg Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Trp Leu Asp Ala Phe Glu Ile Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  56
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  56
atggattgga cctggcgtat tctgtttctg gtggcggcgg cgaccggcgc gcatagccag     60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgcaaggctt ctggatacac cttcaccggc tactatatac actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcag aaactatgca    240

cagaagtttc agggcagggt caccatgacc agggacacgt ccatcagcac agcctacatg    300

gagctgagca ggctgagatc tgacgacacg gccgtgtatt actgtgcgag agaccggtgg    360

ctggatgctt ttgagatctg gggccaaggg acaatggtca ccgtctcttc agctagcacc    420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac    600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc    660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt    720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc    780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg    900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc    960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga   1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc   1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1380

ccgggtaaa                                                           1389


<210>  57
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Arg Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Trp Leu Asp Ala Phe Glu Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  58
<211>  81
<212>  PRT
<213>  Mus musculus

<400>  58

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Ile Asp Ser Leu 
    50                  55                  60                  


Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Val Gln 
65                  70                  75                  80  


Lys 
    


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  59

Trp Ile Asn Pro Asn Ser Gly Gly Arg Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  60

Asp Arg Trp Leu Asp Ala Phe Glu Ile 
1               5                   


<210>  61
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  61

Met Ala Trp Ala Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Asn Phe Met Leu Ala Gln Pro His Ser Val Ser Glu Ser 
            20                  25                  30          


Pro Gly Lys Thr Val Thr Ile Ser Cys Ile Arg Thr Ser Gly Ser Ile 
        35                  40                  45              


Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro 
    50                  55                  60                  


Thr Thr Val Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr 
                85                  90                  95      


Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser 
            100                 105                 110         


Cys Asp Ile Ser Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  62
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  62
atggcgtggg cgccgctgct gctgaccctg ctggcgcatt gcaccggcag ctgggcgaat     60

tttatgctgg ctcagcccca ctctgtgtcg gagtctccgg ggaagacggt aaccatctcc    120

tgtattcgca ccagtggcag cattgccagc aactatgtac agtggtatca gcagcgcccg    180

ggcagttccc ccaccactgt gatctatgag gatgaccaaa gaccctctgg ggtccctgat    240

cgattctctg gctccatcga cagctcctcc aattctgcct ccctcaccat ctctggactg    300

aagactgagg acgaggctga ctactactgt cagtcttgtg atatcagcaa tgtggtattc    360

ggcggaggga ccaagctgac cgtcctaggc caaccgaaag cggcgccctc ggtcactctg    420

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt    480

gacttctacc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg    540

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat    600

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat    660

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                    705


<210>  63
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  63

Asn Phe Met Leu Ala Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ile Arg Thr Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Cys Asp Ile 
                85                  90                  95      


Ser Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  64

Ile Arg Thr Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 
1               5                   10              


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  65

Glu Asp Asp Gln Arg Pro Ser 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  66

Gln Ser Cys Asp Ile Ser Asn Val Val 
1               5                   


<210>  67
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  67

Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Pro Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Gln 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asp Tyr Ala 
65                  70                  75                  80  


Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Ala Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Arg Tyr Tyr Tyr Ser Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  68
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  68
atggattgga cctggagcat tctgtttctg gtggcggcgc cgaccggcgc gcatagccag     60

gttcagctgg tgcagtctgg agctgaggtg aagcagcctg gggcctcagt gaaggtctcc    120

tgcgaggctt ctggttacac cttcaccagc tatggtatca gctgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc agcgcttaca atggtaacac agactatgca    240

cagaagctcc agggcagagt caccatgacc acagacacat ccacgagcgc agcctacatg    300

gagctgagga gcctgagatc tgacgacacg gccgtgtatt actgtgcgag acaacggtat    360

tactacagta tggacgtctg gggccaaggg accacggtca ccgtctcctc agctagcacc    420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac    600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc    660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt    720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc    780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg    900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc    960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga   1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc   1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1380

ccgggtaaa                                                           1389


<210>  69
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asp Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Ala Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Arg Tyr Tyr Tyr Ser Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  70

Ser Tyr Gly Ile Ser 
1               5   


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  71

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asp Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  72

Gln Arg Tyr Tyr Tyr Ser Met Asp Val 
1               5                   


<210>  73
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  73

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Arg Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  74
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  74
atggaaaccc cggcgcagct gctgtttctg ctgctgctgt ggctgccgga taccaccggc     60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc    120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa    180

cctggccagg ttcccaggct cctcatctat ggtacatcca gcagggccac tggcatccca    240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccgtcag cagactggag    300

cctgaagatt ttgcagtgta ttactgtctc cagtatgata ggtcacctcg gacgttcggc    360

caagggacca aggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg    420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc    540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg    600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag    660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                    705


<210>  75
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  75

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Asp Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  76
<211>  127
<212>  PRT
<213>  Rattus rattus

<400>  76

Ala Pro Thr Arg Ser Pro Asn Pro Val Thr Arg Pro Trp Lys His Val 
1               5                   10                  15      


Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu Asn Asp Met Arg Ala Leu 
            20                  25                  30          


Glu Asn Glu Lys Asn Glu Asp Val Asp Ile Ile Ser Asn Glu Phe Ser 
        35                  40                  45              


Ile Gln Arg Pro Thr Cys Val Gln Thr Arg Leu Lys Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Asn Leu Thr Lys Leu Asn Gly Ala Leu Thr Met Ile 
65                  70                  75                  80  


Ala Ser His Tyr Gln Thr Asn Cys Pro Pro Thr Pro Glu Thr Asp Cys 
                85                  90                  95      


Glu Ile Glu Val Thr Thr Phe Glu Asp Phe Ile Lys Asn Leu Lys Gly 
            100                 105                 110         


Phe Leu Phe Asp Ile Pro Phe Asp Cys Trp Lys Pro Val Gln Lys 
        115                 120                 125         


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  77

Gly Thr Ser Ser Arg Ala Thr 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  78

Leu Gln Tyr Asp Arg Ser Pro Arg Thr 
1               5                   


<210>  79
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  79

Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Pro Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Trp Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Trp Leu Asp Ala Phe Asp Ile Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
225                 230                 235                 240 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  80
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  80
atggattgga cctggagcat tctgtttctg gtggcggcgc cgaccggcgc gcatagccag     60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgcaaggctt ctggatacac cttcaccggc tactatatgc actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactatgca    240

cagaagtttc agggcagggt caccatgacc agggacacgt ccatcagcac agcctacatg    300

gagctgagct ggctgagatc tgacgacacg gccgtatatt actgtgcgag agaccggtgg    360

ctggatgctt ttgatatctg gggccaaggg acaatggtca ccgtctctgc tagcaccaag    420

ggcccatcgg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagcggcc    480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc    540

gctctgacca gcggcgtgca caccttccca gctgtcctac agtcctcagg actctactcc    600

ctcagcagcg tggtgaccgt gccctccagc aacttcggca cccagaccta cacctgcaac    660

gtagatcaca agcccagcaa caccaaggtg gacaagacag ttgagcgcaa atgttgtgtc    720

gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct cttcccccca    780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac    840

gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcgt ggaggtgcat    900

aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt ggtcagcgtc    960

ctcaccgttg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac   1020

aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca gccccgagaa   1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg   1140

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg   1200

cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg ctccttcttc   1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc   1320

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg   1380

ggtaaa                                                              1386


<210>  81
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Trp Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Trp Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser 
        115         


<210>  82
<211>  144
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  82

Met Trp Leu Gln Asn Leu Phe Leu Leu Gly Ser Val Val Cys Thr Ile 
1               5                   10                  15      


Ser Ala Pro Thr His Gln Pro Asn Thr Val Ser Gln Pro Leu Lys His 
            20                  25                  30          


Val Asp Ala Ile Lys Glu Ala Arg Ile Ile Leu Ser Arg Ser Asn Asp 
        35                  40                  45              


Ser Ala Ala Val Pro Gly Glu Met Val Glu Val Val Ser Glu Met Phe 
    50                  55                  60                  


Asp Pro Gln Lys Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Glu Arg Leu Ser Ser Thr Leu Thr Leu 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln Asn Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Glu Thr Glu Phe Ile Thr Phe Lys Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Cys Phe Leu Phe Val Ile Pro Phe Asn Cys Trp Glu Pro Val Gln Lys 
    130                 135                 140                 


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence 

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Glu or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Gly or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Pro, Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr, Trp, Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser, Trp, Phe or Thr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Tyr or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa iis Met, Thr or Val

<400>  83

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Asp Xaa 
1               5                   10      


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gln or Leu

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Gln or Leu

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asp, Gly or Phe

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Arg, Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser or Val

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Arg or Trp

<400>  84

Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Thr 
1               5                   


<210>  85
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  85

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Leu Gly Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Leu Ser Ser Ile Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Gly Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ala Thr Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  86
<211>  704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  86
atggaaaccc cggcgcagct gctgtttctg ctgctgctgt ggctgccgga taccaccggc     60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctctagggga aagagccatc    120

ctctcctgca gggccagtca gagtcttagc agcatctact tagcctggta ccagcagaaa    180

cctggccagg ctcccggtct cctcatctat ggtgcttcca gcagggccac tggcatccca    240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag tagtctggag    300

cctgaagatt ttgcagtgta ttactgtcag cagtatgcta cctcaccgtg gacgttcggc    360

caagggacca aggtggaagt caaacgtacg gtggctgcac catctgtctt catcttcccg    420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc    540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg    600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag    660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtg                     704


<210>  87
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  87

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Ser Ile 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Gly Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Thr Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105             


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  88

Arg Ala Ser Gln Ser Leu Ser Ser Ile Tyr Leu Ala 
1               5                   10          


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Ser or Ala

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ser or Ala

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asp or Thr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly, Trp or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val, Leu or Pro

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Val or no amino acid residue

<400>  89

Xaa Xaa Xaa Xaa Asp Ser Ser Asn Xaa Xaa Xaa 
1               5                   10      


<210>  90
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  90

Gln Gln Tyr Ala Thr Ser Pro Trp Thr 
1               5                   


<210>  91
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  91

Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Pro Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Gly Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Arg Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Pro Trp Glu Leu Pro Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  92
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  92
atggattgga cctggagcat tctgtttctg gtggcggcgc cgaccggcgc gcatagccag     60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgcaaggctt ctggattcac cttcagcggc tactatatgt actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactatgca    240

cggaagtttc agggcagggt caccatgacc agggacacgt ccatcagcac agcctacatg    300

gagctgagca ggctgagatc tgacgacacg gccgtatatt actgtgcgag gagaccgtgg    360

gagcttccct ttgactactg gggccaggga accctggtca ccgtctcctc agctagcacc    420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac    600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc    660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt    720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc    780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg    900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc    960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga   1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc   1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1380

ccgggtaaa                                                           1389


<210>  93
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  93

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Pro Trp Glu Leu Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<400>  94

Gly Tyr Tyr Met Tyr 
1               5   


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  95

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Arg Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  96

Arg Pro Trp Glu Leu Pro Phe Asp Tyr 
1               5                   


<210>  97
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  97

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe 
            100                 105                 110         


Ser Phe Pro Ile Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  98
<211>  701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  98
atggaaaccc cggcgcagct gctgtttctg ctgctgctgt ggctgccgga taccaccggc     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaagtca gagcattagc aactatttaa attggtatca gcagaaacca    180

gggaaagccc ctaagctcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca    240

aggttcagtg gcagaggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    300

gaagattttg caacttacta ctgtcaacag agtttcagtt tcccaatcac tttcggccct    360

gggaccaaag tggatatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag    540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg    600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc    660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt g                        701


<210>  99
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  100

Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  101

Thr Ala Ser Ser Leu Gln Ser 
1               5           


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  102

Gln Gln Ser Phe Ser Phe Pro Ile Thr 
1               5                   


<210>  103
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  103

Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Pro Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala His Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Arg Asn Gly Asp Tyr Val Phe Thr Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
225                 230                 235                 240 


Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  104
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  104
atggattgga cctggagcat tctgtttctg gtggcggcgc cgaccggcgc gcatagccag     60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgcaaggctt ctggatacac cttcaccggc tactatatgc actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactatgca    240

cagaagttta agggcagggt caccatgacc agggacacgt ccatcagcac agcccacatg    300

gagctgagca ggctgagatc tgacgacacg gccgtgtatt actgtgtgag aaacggtgac    360

tatgttttta cctactttga ctactggggc cagggaaccc tggtcaccgt ctcctcagct    420

agcaccaagg gcccatcggt cttccccctg gcgccctgct ccaggagcac ctccgagagc    480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    540

aactcaggcg ctctgaccag cggcgtgcac accttcccag ctgtcctaca gtcctcagga    600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca acttcggcac ccagacctac    660

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagacagt tgagcgcaaa    720

tgttgtgtcg agtgcccacc gtgcccagca ccacctgtgg caggaccgtc agtcttcctc    780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacgtgcgtg    840

gtggtggacg tgagccacga agaccccgag gtccagttca actggtacgt ggacggcgtg    900

gaggtgcata atgccaagac aaagccacgg gaggagcagt tcaacagcac gttccgtgtg    960

gtcagcgtcc tcaccgttgt gcaccaggac tggctgaacg gcaaggagta caagtgcaag   1020

gtctccaaca aaggcctccc agcccccatc gagaaaacca tctccaaaac caaagggcag   1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag   1140

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag   1200

agcaatgggc agccggagaa caactacaag accacacctc ccatgctgga ctccgacggc   1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc   1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc   1380

ctgtctccgg gtaaa                                                    1395


<210>  105
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  105

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asn Gly Asp Tyr Val Phe Thr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  106
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Trp or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Tyr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Asn, Ser or Ile

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Pro, Ala, Tyr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Asn or Tyr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Gly or Asn

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Thr or Arg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asn or Asp

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Tyr or Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ala or Asn

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Gln or Arg

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Phe or Lys

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Lys or Arg

<400>  106

Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Gly 
    


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence 

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Try or Phe

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Thr or Ala

<400>  107

Lys Ser Ser Gln Ser Xaa Leu Tyr Ser Ser Xaa Asn Xaa Asn Xaa Leu 
1               5                   10                  15      


Xaa 
    


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  108

Asn Gly Asp Tyr Val Phe Thr Tyr Phe Asp Tyr 
1               5                   10      


<210>  109
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  109

Met Ala Trp Ala Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser 
            20                  25                  30          


Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val 
        35                  40                  45              


Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Met Ile Tyr Glu Val Ser Gly Arg Pro Ser Gly Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile 
                85                  90                  95      


Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe 
            100                 105                 110         


Thr Gly Ser Ser Thr Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  110
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  110
atggcgtggg cgccgctgct gctgaccctg ctggcgcatt gcaccggcag ctgggcgcag     60

tctgccctga ctcagcctgc ctccgtgtct gggtctcctg gacagtcgat caccatctcc    120

tgcactggaa ccagcagtga cgttggtggt tataactatg tctcctggta ccagcagcac    180

ccaggcaaag cccccaaact catgatttat gaggtcagtg gtcggccctc aggggtttct    240

aatcgcttct ctggctccaa gtctggcaac acggcctccc tgaccatctc tggactccag    300

gctgaggacg aggctgatta ttactgcagc tcttttacag gcagcagcac ttggttattc    360

ggcggaggga ccaaactgac cgtcctaggc caaccgaaag cggcgccctc ggtcactctg    420

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt    480

gacttctacc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg    540

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat    600

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat    660

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                    705


<210>  111
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  111

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Gly Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Gly Ser 
                85                  90                  95      


Ser Thr Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  112

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  113

Glu Val Ser Gly Arg Pro Ser 
1               5           


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  114

Ser Ser Phe Thr Gly Ser Ser Thr Trp Leu 
1               5                   10  


<210>  115
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  115

Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Pro Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Phe Gly Tyr Phe Gly Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  116
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  116
atggattgga cctggagcat tctgtttctg gtggcggcgc cgaccggcgc gcatagccag     60

gtgcaactgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgcaaggctt ctggatacac cttcaccggc tactatatgc actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aatcctaaca gtggtggcac aaactatgca    240

cagaagtttc ggggcagggt caccatgacc agggacacgt ccatcagcac agcctacatg    300

gagctgagca ggctgagatc tgacgacacg gccgtgtatt actgtgcgag atttggatat    360

tttggctact actttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc    420

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca    480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac    540

tcaggcgctc tgaccagcgg cgtgcacacc ttcccagctg tcctacagtc ctcaggactc    600

tactccctca gcagcgtggt gaccgtgccc tccagcaact tcggcaccca gacctacacc    660

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agacagttga gcgcaaatgt    720

tgtgtcgagt gcccaccgtg cccagcacca cctgtggcag gaccgtcagt cttcctcttc    780

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg    840

gtggacgtga gccacgaaga ccccgaggtc cagttcaact ggtacgtgga cggcgtggag    900

gtgcataatg ccaagacaaa gccacgggag gagcagttca acagcacgtt ccgtgtggtc    960

agcgtcctca ccgttgtgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc   1020

tccaacaaag gcctcccagc ccccatcgag aaaaccatct ccaaaaccaa agggcagccc   1080

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc   1140

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc   1200

aatgggcagc cggagaacaa ctacaagacc acacctccca tgctggactc cgacggctcc   1260

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc   1320

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg   1380

tctccgggta aa                                                       1392


<210>  117
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  117

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Gly Tyr Phe Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  118
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Gln or Pro

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser or Tyr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val, Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ser or Cys

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ser, Ile, Thr or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Phe or Leu

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ala or Asn

<400>  118

Arg Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa 
1               5                   10          


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  119

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  120

Phe Gly Tyr Phe Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  121
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  121

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Pro Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Trp Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  122
<211>  704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  122
atggaaaccc cggcgcagct gctgtttctg ctgctgctgt ggctgccgga taccaccggc     60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc    120

ctctcctgca gggccagtcc gagtgttagc agcagctact ttgcctggta ccagcaaaaa    180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    300

cctgaagatt ttgcagtgta ttactgtcag cagtatggtt ggtcacctcg gacgttcggc    360

caagggacca aggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg    420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc    540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg    600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag    660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtg                     704


<210>  123
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable domain

<400>  123

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Pro Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Trp Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  124
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  124

Arg Ala Ser Pro Ser Val Ser Ser Ser Tyr Phe Ala 
1               5                   10          


<210>  125
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Ile, Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Arg or Gly

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Arg or Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser, His or Asp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ala or Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Gly or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Tyr or Thr

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Gln, Asn or Ser

<400>  125

Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Asn Xaa Val Xaa 
1               5                   10                  15  


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  126

Gln Gln Tyr Gly Trp Ser Pro Arg Thr 
1               5                   


<210>  127
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  127

Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Pro Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Pro Tyr Thr Ser Gly Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  128
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  128
atggattgga cctggagcat tctgtttctg gtggcggcgc cgaccggcgc gcatagccag     60

gtacaactgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc    120

tgcaaggctt ctggatacac cttcaccggc tactatatgc actgggtgcg acaggcccct    180

ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaattatgca    240

cagaagtttc ggggcagggt caccatgacc agggacacgt ccatcagcac agcctacgtg    300

gagctgagca ggctgagatc tgacgacacg gccgtatatt actgtgcgag agacccgtat    360

accagtggct ttgactactg gggccaggga accctggtca ccgtctcctc agctagcacc    420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac    600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc    660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt    720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc    780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg    900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc    960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga   1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc   1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1380

ccgggtaaa                                                           1389


<210>  129
<211>  118
<212>  PRT
<213>  Artificial Sequence 

<220>
<223>  variable

<400>  129

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Thr Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gly, Thr or Trp

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Ala

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Arg or Leu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ala, Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Thr or Ser

<400>  130

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Glu or Ser

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Asp, Val or Asn

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Asp, Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Gln, Gly or His

<400>  131

Xaa Xaa Xaa Xaa Arg Pro Ser 
1               5           


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  132

Asp Pro Tyr Thr Ser Gly Phe Asp Tyr 
1               5                   


<210>  133
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  133

Met Ala Trp Ala Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser His Ile 
        35                  40                  45              


Gly Ser Asn Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Asn Asn His Arg Pro Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
                85                  90                  95      


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
            100                 105                 110         


Asp Ser Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  134
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  134
atggcgtggg cgccgctgct gctgaccctg ctggcgcatt gcaccggcag ctgggcgcag     60

tctgtgctga ctcagccacc ctcagcgtct gggacccccg ggcagagggt caccatctct    120

tgttctggaa gccgctccca catcggaagt aatactgtaa actggtacca gcacctccca    180

ggaacggccc ccaaactcct catctatagt aataatcatc ggccctcagg ggtccctgac    240

cgattctctg gctccaagtc tggcacctca gcctccctgg ccatcagtgg gctccagtct    300

gaggatgagg ctgattatta ctgtgcagca tgggatgaca gcctgaatgg tccggtattc    360

ggcggaggga ccaagctgac cgtcctaggc caaccgaaag cggcgccctc ggtcactctg    420

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt    480

gacttctacc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg    540

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat    600

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat    660

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                    705


<210>  135
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence

<400>  135

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser His Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  136
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  136

Ser Gly Ser Arg Ser His Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  137

Ser Asn Asn His Arg Pro Ser 
1               5           


<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  138

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  139
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  139

Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Pro Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Arg Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Glu Asp Thr Ala Met Asp Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
225                 230                 235                 240 


Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  140
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  140
atggattgga cctggagcat tctgtttctg gtggcggcgc cgaccggcgc gcatagccag     60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cacagaccct gtccctcacc    120

tgcactgtct ctggtggctc catcagaagt ggtggttact actggagctg gatccgccag    180

cacccaggga agggcctgga gtggattggg tatatctatt acagtgggag cacctactac    240

aacccgtccc tcaagagtcg agttaccata tcagtagaca cgtctaagaa ccagttctcc    300

ctgaagctga actctgtgac tgccgcggac acggccgtgt attactgtgc gagagaggat    360

acagctatgg actactttga ctactggggc cagggaaccc tggtcaccgt ctcctcagct    420

agcaccaagg gcccatcggt cttccccctg gcgccctgct ccaggagcac ctccgagagc    480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    540

aactcaggcg ctctgaccag cggcgtgcac accttcccag ctgtcctaca gtcctcagga    600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca acttcggcac ccagacctac    660

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagacagt tgagcgcaaa    720

tgttgtgtcg agtgcccacc gtgcccagca ccacctgtgg caggaccgtc agtcttcctc    780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacgtgcgtg    840

gtggtggacg tgagccacga agaccccgag gtccagttca actggtacgt ggacggcgtg    900

gaggtgcata atgccaagac aaagccacgg gaggagcagt tcaacagcac gttccgtgtg    960

gtcagcgtcc tcaccgttgt gcaccaggac tggctgaacg gcaaggagta caagtgcaag   1020

gtctccaaca aaggcctccc agcccccatc gagaaaacca tctccaaaac caaagggcag   1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag   1140

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag   1200

agcaatgggc agccggagaa caactacaag accacacctc ccatgctgga ctccgacggc   1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc   1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc   1380

ctgtctccgg gtaaa                                                    1395


<210>  141
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence

<400>  141

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Arg Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Asp Thr Ala Met Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  142

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  143

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  144

Glu Asp Thr Ala Met Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  145
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GM-CSF-Ile

<400>  145

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Leu Arg Leu Leu Asp Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Glu Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Lys Pro Val Gln Glu 
        115                 120                 125         


<210>  146
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  146

Ala Pro Ser Arg Ser Pro Ser Pro Ser Arg Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Ile Asn Glu Thr Val Glu Val Val Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Thr Pro Phe Asp Cys Trp Glu Pro Val Gln Gly 
        115                 120                 125   


<210>  147
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gly or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Gly or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Thr, Ser or Gly

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Gly

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ile or Met

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is His or Ser

<400>  147

Xaa Xaa Gly Xaa Xaa Phe Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10       


